It took a long time to develop it in conjunction with Dulux but Crimsafe® stuck at it 'til it was right. One last fact… The coating that goes on Crimsafe's® stainless steel mesh gives it that cool black look, but it is purposefully designed to protect it from the environment. Secret coating means long life and good looks 9mm Premium 304 grade Security Steel into the commercial mesh that Crimsafe® is made of! Crimsafe® had to commission a wire products manufacturer to make special machinery before it could be done. It's an incredibly tough test to pass, but Crimsafe ® does it easily.īut the real proof that Crimsafe's® Tensile Tuff® Security mesh is something special is this… before Crimsafe® came on the market, nobody could even weave. You can see that Crimsafe® is successful because the tip of the knife doesn't penetrate the mesh, it just skips over it. There's 15kg of force pushing the knife into the mesh, and 30kg's pulling it along the face of the mesh. Take a look below at how Crimsafe ® mesh stands up to an Australian Standards test called, funnily enough, “The Knife Shear Test”. What that means is that a burglar can't make a hole in the mesh by stabbing it, and then make it bigger by using his weight to drag a knife through it. That's because Crimsafe's® Security mesh has such strong ‘shear' resistance. You might put a few holes in it but you won't be able to fit through them. You can take a machete and hack away at the mesh and you'll have a hard time getting anywhere. It's also incredibly difficult to cut Crimsafe® Tenisle Tuff® Security mesh. You can kick at Crimsafe's® Tensile Tuff ® Security mesh repeatedly, and you will definitely injure yourself before you break through it. Research shows that the most common method of entry through security screens is a well-placed series of kicks that bust the screen apart. Only Crimsafe® features screws driven through both the clamp and the mesh and right into the frame on the other side, to provide incredible strength. This system is internationally patented and unique. ![]() This combination mechanically fastens the mesh to the frame and creates a barrier that can't be kicked in – The Screw-ClampedTM Mesh that Beats More Burglars. But then, all three are screwed together with stainless steel tamper-resistant screws and the different components are separated by a Santoprene (rubber) bead to eliminate electrolysis that could lead to corrosion. One is an aluminium strip with a hook and the other is the frame that the strip hooks into. Look at the picture at right and you can see how the Crimsafe® mesh is sandwiched between two serrated pieces of aluminium that clamp the mesh tight.
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![]() Reduces tissue penetration (only free drug is able to leave the bloodstream and penetrate tissues).Reduces renal clearance (only free drug is cleared).Creates a reservoir of drug which is bound to albumin (which may extend the drug's half-life).A high percent protein binding (>90%) may have the following consequences:.Only unbound drug is active against bacteria. Protein binding refers to the percent of drug in the blood which is bound to albumin.A recent analysis of over fifty RCTs found no benefit of cidal antibiotics compared to static antibiotics, so the clinical superiority of cidal antibiotics may be mostly mythological.Just because an antibiotic is bacteriostatic doesn't mean that it's not extremely effective. In some situations this may be important, but other factors may be equally if not more important (e.g. Overall, the focus on cidality is probably misplaced.Severe neutropenia is one situation where the petri-dish model may actually be accurate, so cidal antibiotics might be desirable in that context.However, this model isn't very accurate – in vivo, the antibiotic is just assisting the patient's immune system in containing the infection. The concept that bactericidal antibiotics are superior is based on a petri-dish model of infectious disease, wherein the antibiotic is relied upon to kill the bacteria.They are used specifically for this reason – to shut down toxin synthesis (rather than necessarily immediately destroying all the bacteria). clindamycin and linezolid) cause immediate cessation of toxin secretion in patients with toxic shock. For example: Antibiotics which inhibit protein synthesis (e.g.endotoxin) causing uncontrolled inflammation. However, cidality may actually be dangerous if this leads to rapid lysis of bacteria leading to a huge release of bacterial products (e.g. Traditionally it was believed that cidality was desirable for severe infections.An antibiotic which is bactericidal kills bacteria, whereas an antibiotic which is bacterio static stops bacteria from dividing.Urinary drug concentrations depend on serum level, percent excreted in the urine, and how concentrated the urine is.Likewise, excretion of unchanged drug in the bile is ideal for biliary or intestinal infections. Excretion of unchanged drug in the urine is ideal for treatment of urinary tract infections, because this will often produce very high drug concentrations in the kidney and bladder. ![]() Hepatic metabolism/excretion is generally convenient, because this means the drug dose doesn't need to be adjusted based on renal function.Antibiotics may be metabolized in the liver (often into inactive metabolites) or they may be excreted unchanged in the urine or bile.Specific properties of various antibiotics Requirement for surgical/percutaneous drainage.volume overload, superinfection at different site, drug fever) Development of a new hospital-related problem (e.g.Common causes of treatment failure include:.If a patient is failing antibiotic therapy, broadening coverage is usually not the answer.Use of procalcitonin has been shown to limit antibiotic exposure, while possibly improving patient outcomes.Have some sort of plan regarding when to discontinue antibiotics and follow it. Keep track in your notes of how long the patient has been on each antibiotic.Try to choose antibiotics that cover pathogens that the patient has grown in the recent past. Review which antibiotics patient has been exposed to recently try to avoid these if possible.Septic patients may have increased drug clearance, so antibiotics should generally be dosed on the higher end of dose ranges.If possible, get cultures before starting antibiotics.Don't treat colonization except in very specific situations (e.g. Colonization commonly occurs in the bladder of anuric or catheterized patients, or sputum of intubated patients. A positive culture may represent infection or colonization (bacteria present without causing disease).Antibiotics shouldn't be started blindly (without a defined source of infection) unless the patient has septic shock or neutropenic fever.Patients are critically ill, so we're justified in using broad-spectrum agents initially. cefepimeĪntibiotics in the ICU are in some ways simpler than antibiotic therapy for less ill patients. □ Drug-resistant gram positive cocci: vancomycin vs.Some common antibiotic selection debates:.Extended-spectrum beta-lactamases (ESBL).Drug-resistant organisms of particular importance.Macrolides (Azithromycin, Clarithromycin).General considerations for antibiotic therapy. ![]() Whether you are looking for discreet marijuana edibles you can take on-the-go, or you’re seeking the best hybrid cannabis strain for pain relief, the Life Flower Dispensary team will help you navigate our wide selection of products and choose the best fit for you. 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Airis Dabble Dual Use Wax vaporizer Glass Bong Connector, Rechargable, DABBING VAPORIZER COLORS TO CHOOSE FROM BLACK WHITE GRADIENT RAINBOW This product is currently out of stock and unavailable. ![]() ![]() Our medical marijuana dispensary has built a team with years of experience with organic Medical cannabis products. A scoop in the center of the hood, and gun sight toppers in chrome for the front tops of the fenders, along with dual chromed side view mirrors hanging off the backs of the quarters the front of this car is screaming you've arrived. Dual headlights snugly fitted under the red visors and floating over the big chrome bumper with lower egg crate grille smiling as it leads the way, we blend the front quarters next to the hood and gaps are near perfect. A Thunderbird says action everywhere it goes, just like the TV ads of the day said.Ĭhiseled and smoothed steel undulates in and out and forms the exterior of this car like no other. A fresh engine rebuild, along with the transmission, not only does it look fabulous, but runs and drives this way as well. From its deep end of the pool red paint, to the white canvas convertible top, room for 4, and all its trappings of design for this year, you are looking at one of the best of the best. With 64,033 original low miles, this car presents beautifully. It was the talk of the town, and Americans everywhere wanted to be seen driving one.įor consignment a square bird from 1960, the last year for this design, and they had it all right by this year. ![]() Sales skyrocketed, and the all-new, bigger, roomier and more practical Thunderbird became the must-see car in Ford showrooms that year. Adding those two extra seats in the back changed everything. ![]() ![]() For the era, they were sensational-looking cars-they still are today-but not everyone who lusted after a 1955-'57 Thunderbird could justify buying one due to their limited seating capacity. 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OFF Letyshops Promo Codes ➡️ ( Letyshops Coupon Codes) June 2023 USA Today's top Letyshops coupons & deals FREE USA: You can find perfect offers on Letyshops. ![]() ![]() Simplified Chinese was widely adopted in the mainland and Singapore. This not only helped us learn the Chinese language quicker, but also increased levels of literacy throughout China. Simplified Chinese was introduced in 1949 to help Westerners understand the language and Chinese characters. Mandarin and Cantonese are dialects, while Simplified Chinese and Traditional Chinese are two different ways of writing Chinese, both with different kinds of symbols and characters. However, there is no direct relationship between the two. There is a common misconception that Simplified Chinese corresponds to Cantonese and Traditional Chinese to Mandarin, or the other way around. People have had to learn It in order to do business with China. Even if you travel to Cantonese speaking regions, you will be able to communicate in Mandarin. If you are travelling to China for business or holiday and are wondering which dialect to learn, we would always advise learning Mandarin, as at the end of the day, it’s the official language. ![]() These regions include, but are not exclusive to Shanghai (a dialect known as Shanghainese), Tibet, and the northern regions near Mongolia, Korea and Xinjiang. These people will most likely have a lack of knowledge of Mandarin. There are also many other regions in China where regional languages are still in use. It’s worth mentioning that most foreign communities in London and San Francisco speak Cantonese because, historically, Chinese immigrants come from Guangdong. It is being taught in schools and used on national TV and radio.Ĭantonese is used by people living in Hong Kong, Macau and the Guangdong province, including Guangzhou. Mandarin is also the main dialect in Taiwan and Singapore. Mandarin is the official language of China and the primary spoken language in much of the country, including Beijing and Shanghai. Though Hong Kong residents are now learning Mandarin as a second language, they will, for the most part, not speak the language. This doesn’t mean that people from Hong Kong and Beijing can understand each other perfectly. Similarly in China, a person living in Hong Kong will speak with a Cantonese dialect and a person living in Beijing (or elsewhere on the mainland) will speak with a Mandarin dialect. They both speak English but with very different regional dialects (or accents) making them sound very unalike. To put this into context, think of a British person from Bournemouth and a British person from Manchester speaking English. They share the same alphabet, but they sound very different. They are dialects of the same Chinese language. Mandarin and Cantonese are the same language. Let us explain… The difference between Mandarin and Cantonese However, what many of us don’t realise is that the question to ask isn’t whether the document should be translated into Mandarin or Cantonese, but whether it needs to be translated into Traditional or Simplified Chinese. Does it mean the document needs to be translated into the Mandarin or Cantonese language? Imagine being asked to get a document translated into the Chinese language. Home ▸ Blog ▸ Chinese Translation – Do you need Mandarin or Cantonese translation? Chinese Translation – Do you need Mandarin or Cantonese translation? ![]() Sometime in early 2012, an image macro based on the screen capture of Ron Burgundy from the dialogue scene began appearing on Reddit, FunnyJunk and Tumblr as a reaction image. Another YouTube clip of the dialogue scene was uploaded by YouTuber Courage11235 on April 14th, 2011.īeginning in 2010, the phrase became increasingly used as the title or the tag of various image, video or discussion posts on 4chan and Reddit, most notably with videos depicting public fights, screenshots of arguments in chatrooms and discussion threads relating to relationships and dating. 'Escalate' can also be used in a positive sense like, for example, a love relationship. If it escalates quickly, it means it gets worse quickly. If a problem escalates, it means it gets worse. Now, in your mind, make the escalator go really fast. On September 17th, 2008, YouTuber ScopeStyle posted a kinetic-typographical video based on the dialogue from the scene. English (US) English (UK) This of an escalator going up. ![]() The quote was included in the YouTube compilation video "The Top Ten Lines from Anchorman-The Legend of Ron Burgundy" uploaded on July 20th, 2008, which has gained more than 1.2 million views in the span of four years. The earliest known use of the phrase outside of its original context can be found on the webcomic blog I Heart Eddit in a comic titled "In Which Eddie & Logan Make Like A Banana" posted on December 2nd, 2007. Lay low for a while, because you're probably wanted for murder.Īlong with many other memorable lines from the movie, Ron Burgundy's afterthought continued to be quoted in various comedy and movie discussion forums, as well as in comments of news articles and discussion threads as a general notion that something has gone out of control quickly. You should probably find yourself a safe house or a relative close by. Ron Burgundy: Brick, I've been meaning to talk to you about that. Ron Burgundy: I saw that! Brick killed a guy! Did you throw a trident?īrick Tamland: Yeah, there were horses, and a man on fire, and I killed a guy with a trident. I mean, that really got out of hand fast!īrick Tamland: Yeah, I stabbed a man in the heart. Ron Burgundy: Boy, that escalated quickly. ![]() The quote "well, that escalated quickly, really that got out of hand fast!* was originally heard in a scene from the 2004 comedy film Anchorman: The Legend of Ron Burgundy, in which Ron Burgundy and his co-anchors discuss their previous encounter of a violent midday brawl with the rival KQHS Channel 9 Evening News Team. ![]() Whether you are looking for a subtle and stylish cocktail ring or something with a little extra glamour and glitter, our silver and white gold citrine rings belong on your finger. 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![]() This is present throughout the film – from the revolving space station, through the Discovery cockpit, to the HAL-9000’s all-seeing eye, and a lot more.Ħ. In order to reflect the theme of evolution present in the narrative, Kubrick had Unsworth create visuals with circular imagery. Together, Unsworth and Kubrick created some of the most iconic visuals ever committed to Hollywood film – visuals with thematic depth. ![]() The Director of Photography on the film was Geoffrey Unsworth, a highly experienced cinematographer who had worked on classics like A Town Like Alice (1956), A Night To Remember (1958), and Genghis Khan (1965). Kubrick presented with the award at the Oscars Deemed by many to be unfair, Academy rules were changed to allow multiple names to be nominated per film in the Best Visual effects category. Oscar rules at the time dictated that only one name could be submitted for the award, despite the fact that the film credited 4 other names in this area (Douglas Trumbull, Tom Howard, Con Pederson and Wally Veevers). Kubrick won his only Oscar for the filmįor spearheading the pioneering visual effects on the film, Stanley Kubrick won an Oscar for Best Special Visual Effects – his only individual Academy Award. Poole’s gravity-defying jog aboard the DiscoveryĤ. Since 2001, we’ve seen a rotating set used by big name filmmakers like Wes Craven, James Cameron, and Christopher Nolan. Kubrick commissioned an aeroplane manufacturer called Vickers Armstrong to build a 36ft centrifuge that cost $750k. Revolving sets had been used by Hollywood before – like when Fred Astaire danced on the ceiling in Royal Wedding (1954) – but never on this scale. These were largely created by using revolving sets. A space hostess walking up the walls at one point and astronaut Frank Poole jogging across the ceiling are two examples. There are many scenes in 2001 which involves characters or objects defying gravity. The ‘space waltz’ in 2001: As Space Odysseyģ. Motion control was then developed further by ILM when they provided the visual effects for Star Wars in 1977 ![]() The track moved at a rate of 4 inches per minute. The model ships were moved along tracks at exact speeds which meant the film crew could replicate the shot over and over again precisely. To pull this off, the effects team on 2001 developed a technique called Motion Control. It was used to create the effect of the Enterprise going into warp in Star Trek, for example.Īlso, the psychedelic effect of the stargate sequence apparently led to people dropping acid before going to watch the film.Ģ001: A Space Odyssey is famous for its majestic and realistic-looking shots of the spaceships – visuals of a level way beyond anything that came before. That’s how they create the Stargate, and it was also used later in many classic science fiction series and movies. He’d film objects passing behind the glass and it would create an on screen illusion of seemingly stretching the object. He had a piece of glass with a slit in the centre. It’s a minutes long whirl of colour and surreal imagery, and creating it would have been previously impossible.Īudiences hadn’t seen anything like this before, and it was the brainchild of special effects supervisor, Doug Trumbull. This is a gateway to the final sequence where Bowman evolves into the next stage of humanity. Towards the end of the film, astronaut Dave Bowman enters the Stargate. An innovative visual technique was developed We have the full behind the scenes story of a masterpiece, by way of 25 huge, interesting facts about 2001: A Space Odyssey.ġ. Ground breaking in its scale, its storytelling, its ambition, and its technical innovations, the film cemented Stanley Kubrick’s status as a filmmaking genius and made an impact still felt in Hollywood today. 2001: A Space Odyssey was released in 1968 and changed science fiction movies forever. |
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